Jim Fogleman
Professor
http://portfolio.du.edu/fogleman
Seeley G. Mudd Building, 2101 E. Wesley Ave. Denver, CO 80208
What I do
As a Professor, I teach the courses General Genetics and Biostatistics and do research in human forensic genetics.Specialization(s)
Genetics; Biostatistics; Coral Reef Ecology
Professional Biography
Degrees, professional certificates:
1972 B.S., Biology, University of New Mexico, Albuquerque
1974 M.S., Zoology, Colorado State University, Ft. Collins
1979 Ph.D., Genetics, Cornell University, New York
Professional experience:
1978-80 N.I.H. (NRSA) Postdoctoral Fellow, Department of Ecology and Evolutionary Biology, University of Arizona, Tucson
1980-82 Research Associate, Department of Ecology and Evolutionary Biology, University of Arizona, Tucson
1983 Visiting Assistant Professor, Section of Genetics and Development, Cornell University, Ithaca, New York
1983-88 Assistant Professor, Department of Biological Sciences, University of Denver, Denver, Colorado
1988-94 Associate Professor, Department of Biological Sciences, University of Denver, Denver, Colorado
1990 Visiting Associate Professor, Section of Genetics and Development, Cornell University, Ithaca, New York
1994- Professor, Department of Biological Sciences,
Present University of Denver, Denver, Colorado
2000-01 Associate Chair, Department of Biological Sciences,
University of Denver, Denver, Colorado
2001-02 Interim Dean; Division of Natural Sciences, Mathematics, and
Engineering; University of Denver, Denver, Colorado
2002-07 Dean; Division of Natural Sciences, Mathematics, and
Engineering (which subsequently became Natural Sciences and Mathematics); University of Denver, Denver, Colorado
1972 B.S., Biology, University of New Mexico, Albuquerque
1974 M.S., Zoology, Colorado State University, Ft. Collins
1979 Ph.D., Genetics, Cornell University, New York
Professional experience:
1978-80 N.I.H. (NRSA) Postdoctoral Fellow, Department of Ecology and Evolutionary Biology, University of Arizona, Tucson
1980-82 Research Associate, Department of Ecology and Evolutionary Biology, University of Arizona, Tucson
1983 Visiting Assistant Professor, Section of Genetics and Development, Cornell University, Ithaca, New York
1983-88 Assistant Professor, Department of Biological Sciences, University of Denver, Denver, Colorado
1988-94 Associate Professor, Department of Biological Sciences, University of Denver, Denver, Colorado
1990 Visiting Associate Professor, Section of Genetics and Development, Cornell University, Ithaca, New York
1994- Professor, Department of Biological Sciences,
Present University of Denver, Denver, Colorado
2000-01 Associate Chair, Department of Biological Sciences,
University of Denver, Denver, Colorado
2001-02 Interim Dean; Division of Natural Sciences, Mathematics, and
Engineering; University of Denver, Denver, Colorado
2002-07 Dean; Division of Natural Sciences, Mathematics, and
Engineering (which subsequently became Natural Sciences and Mathematics); University of Denver, Denver, Colorado
Degree(s)
- BS, Biology, University of New Mexico
- MS, Zoology, Colorado State University
- Ph.D., Genetics, Cornell University
Licensure / Accreditations
- Master Scuba Diver Trainer
- Open Water Scuba Instructor
Professional Affiliations
- Professional Association of Diving Instructors
Research
My current interests involve the relevance of cytochrome P450 polymorphism in forensic medicine and akathisia-related acts of violence. Violence and mortality caused by psychiatric drugs do not receive much attention from forensic medical examiners. Akathisia, the most dangerous adverse drug reaction reported for these drugs, is hardly known and seldom recognized within the forensic medical community. By using data from suicide epidemiology, medication as a cause of suicide, homicide and other violence has been accepted in legal cases. The cytochrome P450 (CYP) enzyme system is primarily responsible for the metabolism of most psychoactive medication, including antidepressants. Diminishing mutations in these CYP genes, called polymorphisms, have an impact on the metabolism of these drugs and their half-lives. DNA tests for these enzyme-producing genes can now be used to predict toxicity and adverse drug reactions which produce akathisia. These reactions can be immediate or delayed. Cause and manner of death, as established by a coroner, have far reaching implications. Suicide committed while in a toxic state might be ruled an accident. Homicide, when committed involuntarily by a person affected by a prescribed medication, elicits a different legal defense than the same act committed by a mentally ill person. The correct diagnosis provides an accused person with a defense of “not guilty by reason of involuntary intoxication” or “non-insane automatism”. Thus, the interactions between drugs and these genes are crucially important in a medico-legal context.
Areas of Research
Cytochrome P450 genes/enzymes; Psychotropic drugs; SSRIs; Acts of violence; Forensic medicine
Featured Publications
(2018). Letter to the Editor - Pharmacogenomics. London, United Kingdon: Pharmacogenomics.
. Presentations
(2016). Cytochrome P450, SSRI's and Violence. Individualizing Medicine, Advancing Care Through Genomics. Rochester, Minnesota: Mayo Clinic.
. (2015). From personalized medicine to personalized justice: The promises of translational pharmacogenomics in the justice system. Pharmacogenetic assessment of three homicides. . 2015 APSA-ASCEPT. Hobart, Tasmania, Australia: The Australasian Pharmaceutical Science Association (APSA) and The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologist (ASCEPT.
. (2016). The relevance of Cytochrome P450 Polymorphism in forensic medicine and akathisia-related violence and suicide. GPS 2016: "Goals, Purposes and Strategies for Prisoner and Staff Mental Wellbeing in Custody". Fremantle, Western Australia: The Royal Australian and New Zealand College of Psychiatrists.
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