Michelle Knowles photo

Michelle Knowles

Associate Professor

  • Faculty

What I do


Professional Biography

Ph.D. Chemistry, University of Oregon, 2003
M.S. Chemistry, University of Oregon, 1999
B.S. Chemistry, University of Michigan-Flint, 1998

Professional Affiliations

  • Biophysical Society



Key Projects

  • CAREER: Development of nanoparticle based niosensors to characterize the role of nanoscale topology in neurotransmission
  • Progress Towards Understanding Neurotransmission: Temporal mapping of Phospholipase D activity in Exocytosis

Featured Publications

Barg, S., Knowles, M. K., Chen, X., Midorikawa, M., & Almers, W. (2010). Syntaxin clusters assemble reversibly at sites of secretory granules in live cells. Proceedings of the National Academy of Science U.S.A., 107(48), 20804-20809.
Knowles, M. K., Barg, S., Wan, L., Midorikawa, M., Chen, X., & Almers , W. (2010). Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers. Proceedings of the National Academy of Science U.S.A., 107(48), 20810-20815.
Black, J. C., Cheney, P. P., Campbell, T., & Knowles, M. K. (2014). Membrane Curvature Based Lipid Sorting Using a Nanoparticle Patterned Substrate. Soft Matter/ RSC, 10(12), 2016-2023.
Alnaas, A. A., Moon, C. L., Alton, M., Reed, S. M., & Knowles, M. K. (2017). Conformational Changes in C-Reactive Protein Affect Binding to Curved Membranes in a Lipid Bilayer Model of the Apoptotic Cell Surface. Journal of Physical Chemistry B, 121(12), 2631-2639 .


  • Faculty Early Career Award (CAREER) , National Science Foundation
  • Marie Curie and Vinnmer Fellow, Vinnova
  • Barton L. Weller Chair, DU NSM